Organelle Motility: Running on Unleadened
نویسندگان
چکیده
منابع مشابه
Organelle Motility: Running on Unleadened
The study of fish and amphibian melanocytes has yielded a wealth of information on the regulation of microtubule- and actin-based motor proteins involved in organelle transport. A new zebrafish mutant provides further insight into how the actions of these motors are coordinated in vivo.
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We previously prepared cell lines that inducibly overexpress MAP4, a microtubule (MT)-associated protein widely expressed in non-neuronal cells. Overexpression of either the full-length MAP4 molecule or its MT-binding domain, MTB, stabilized MTs and retarded cell growth, suggesting that overexpressed MAP4 impacts on MT-dependent functions in vivo. To test this hypothesis, we examined MT-based v...
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24 Introduction. Pancreatic polypeptide (PP) is an anorexigenic hormone released from 25 pancreatic F-cells upon food intake. We aimed to determine the effect of PP on 26 gastric accommodation and gastric emptying in conscious Wistar HAN rats to 27 investigate whether effects on motor function could contribute to its anorexigenic 28 effects. Methods. Intragastric pressure (IGP) was measured thr...
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Background: The barostat is considered the gold standard for evaluation of proximal gastric motility especially for the accommodation response to a meal. The procedure is invasive because it involves the introduction of an intragastric catheter and bag and is not always well tolerated. Moreover, the barostat bag itself may influence motility. Nowadays Magnetic Resonance Imaging (MRI) is able to...
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PICK1 is a modular scaffold implicated in synaptic receptor trafficking. It features a PDZ domain, a BAR domain, and an acidic C-terminal tail (ACT). Analysis by small- angle x-ray scattering suggests a structural model that places the receptor-binding site of the PDZ domain and membrane-binding surfaces of the BAR and PDZ domains adjacent to each other on the concave side of the banana-shaped ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2007.10.010